Publications by authors named "F Cuzin"
Article Synopsis
- Researchers found that certain microRNAs are present at low levels in individuals with Autism Spectrum Disorder (ASD) and created mouse models to study this.
- They experimented by microinjecting specific microRNAs into mouse zygotes to determine if altering their levels could impact behavior and genetics related to ASD.
- The study revealed that manipulating these microRNAs can lead to notable changes in their expression, which is also echoed in blood samples from human ASD patients.
Article Synopsis
- * In a study of 45 children with ASD, six specific microRNAs were found at significantly lower levels in their serum compared to healthy controls, and similar patterns were observed in unaffected parents and siblings.
- * Mouse models of ASD also showed a consistent microRNA profile, suggesting a genetic link and potential for early identification of ASD, which could lead to better diagnostic methods in the future.
Mature spermatozoa contain a whole repertoire of the various classes of cellular RNAs, both coding and non-coding. It was hypothesized that after fertilization they might impact development, a claim supported by experimental evidence in various systems. Despite the current increasing interest in the transgenerational maintenance of epigenetic traits and their possible determination by RNAs, little remains known about conservation in sperm and across generations and the specificities and mechanisms involved in transgenerational maintenance.
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