Publications by authors named "F Curreli"
Monitoring the conservation status of endangered freshwater fish using less invasive methods poses challenges for ecologists and conservationists. Visual surveys have been proposed as an alternative to electrofishing, which is a standard methodology that can cause injuries, physiological stress and post-release mortality in organisms. To test the efficacy of visual methods, a study was conducted in an intermittent stream of Sardinia (Italy).
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- The COVID-19 pandemic, triggered by the SARS-CoV-2 virus and its variants, has led to significant global health and economic crises, highlighting the necessity for new treatments.
- Researchers have discovered a small-molecule inhibitor called NBCoV63 that shows strong antiviral activity against multiple coronaviruses, including SARS-CoV-2 and its variants, with a potency comparable to existing treatments like Remdesivir.
- NBCoV63 not only inhibits virus activity effectively but also shows favorable drug-like properties in terms of absorption, distribution, metabolism, and excretion (ADME).
As part of our effort to discover drugs that target HIV-1 entry, we report the antiviral activity and crystal structures of two novel inhibitors in a complex with a gp120 core. NBD-14204 showed similar antiviral activity against all the clinical isolates tested. The IC values were in the range of 0.
View Article and Find Full Text PDFWe earlier reported substantial progress in designing gp120 antagonists. Notably, we discovered that NBD-14189 is not only the most active gp120 antagonist but also shows antiviral activity against HIV-1 Reverse Transcriptase (RT). We also confirmed its binding to HIV-1 RT by X-ray crystallography.
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- The envelope glycoprotein gp120 of HIV-1 is essential for the virus to enter human cells by attaching to the CD4 protein.
- Researchers previously developed effective small-molecule entry antagonists with a thiazole ring structure (Scaffold A) and are now investigating other thiazole isomers (Scaffolds B and C) to understand their impact on antiviral effectiveness and cell safety.
- The study's findings suggest that Scaffold A is the most effective in inhibiting HIV-1, showing greater potency and a better selectivity index compared to the new isomers.