Kinetic stability of all-in-one parenteral nutrition admixtures in the presence of high dose Ca2+ additive under clinical application circumstances.

Background: TPN infusions are usually administered during a treatment period of 10-24 hours per day due to the metabolic capacity of the liver. During this time interval physicochemically stable TPN solution (emulsion) is needed for the treatment. The purpose of the present study was to examine how the kinetic stability features of ready-made total parenteral nutrition admixtures containing olive oil and soybean oil will change under the usage-modeling 24-hour application with and without overdose Ca2+.

Comparison of the physicochemical properties of MCT-containing fat emulsions in total nutrient admixtures.

The physical stability of two types of MCT-emulsions made by different technologies - physical mixture vs. structured lipids - was studied as a function of storage time and temperature. Particle size analysis, zeta potential and dynamic surface tension measurements were carried out to evaluate the possible changes in the kinetic stability of the emulsions.

[Colloid-physical characterization of supramolecular drug delivery systems].

Cyclodextrins are well-known biocompatible oligosaccharides capable of forming inclusion complexes with suitable guest molecules. They can be expediently used as solubilizers for hydrophobic pharmacon molecules in aqueous solutions. In this study, the effect of colloidal and non-colloidal additives on the solubility of statins is described.

Enhancement of drug solubility in supramolecular and colloidal systems.

Statins, as efficient HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme-A) reductase inhibitors are widely used in the management of cardiovascular diseases. Interactions in aqueous solutions between highly lipophilic statins and cyclodextrins (CDs) in the absence and the presence of a dissolved polymer or its monomeric compound, respectively, were studied. The solubility of lovastatin and simvastatin at various temperatures and pHs were investigated by phase-solubility measurements.

Influence of cyclodextrins on the physical stability of DPPC-liposomes.

This paper reports on the physical stability of DPPC-(dipalmitoyl phosphatidyl choline) liposomes in various aqueous dispersions and its control by uncharged polymers. The effect of natural (alpha-, beta-, gamma-) cyclodextrins (CDs) on the stability of bare and polymer-bearing liposomes and also, the attachment of the CD molecules and the macromolecules, respectively, to the DPPC-bilayers of small unilamellar vesicles (SUV) were studied. It was found that above a CD/DPPC ratio, each cyclodextrin caused a definite destruction in the phospholipid bilayers.