Publications by authors named "F Crouwel"
Multicentre study and systematic review: Allopurinol exposure during pregnancy.
Aliment Pharmacol Ther
August 2024
Article Synopsis
- This study looked at how safe the medicine allopurinol is for pregnant women, especially those with a condition called inflammatory bowel disease (IBD).
- Researchers gathered data from 42 pregnancies where mothers took allopurinol and found some complications, like miscarriages and a baby born with a heart issue.
- Overall, the findings suggest that allopurinol might not significantly increase the risk of birth defects in babies born to mothers with IBD who took this medicine.
Thiopurine treatment is regularly complicated by drug-induced liver injury. It has been suggested that oxidative stress may play a synergistic role. To assess whether thiopurine-induced liver injury coincides with increased oxidative stress and whether co-administration with N-acetylcysteine is protective, we performed a randomized open label crossover pilot study in inflammatory bowel disease patients with thiopurine-induced increased serum liver tests.
View Article and Find Full Text PDFBackground: Currently thioguanine is solely used as treatment for inflammatory bowel disease after azathioprine and/or mercaptopurine failure. This study aimed to determine the safety, effectiveness, and 12-month drug survival of thioguanine in thiopurine-naïve patients with inflammatory bowel disease.
Methods: A retrospective cohort study was performed in thiopurine-naïve patients with inflammatory bowel disease treated with thioguanine as first thiopurine derivate.
Background: Safety of thioguanine in pregnant patients with inflammatory bowel disease [IBD] is sparsely recorded. This study was aimed to document the safety of thioguanine during pregnancy and birth.
Methods: In this multicentre case series, IBD patients treated with thioguanine during pregnancy were included.
Background: Home use of a buffer-containing extraction device for fecal calprotectin determination can bypass the labor-intensive extraction procedure and potentially prevent degradation at room temperature.
Methods: In this prospective cross-sectional observational study, 2 CALiaGold tubes (extraction device) and one native tube were filled from the same bowel movement by patients with inflammatory bowel disease. Afterwards patients completed a questionnaire including whether they preferred the extraction device or the normal sampling method.