Immune-Checkpoint Inhibitors for Malignant Pleural Mesothelioma: A French, Multicenter, Retrospective Real-World Study.

Backgrounds: Malignant pleural mesothelioma (MPM) is a cancer with poor prognosis. Second-line and onward therapy has many options, including immune-checkpoint inhibitors with demonstrated efficacy: 10−25% objective response rate (ORR) and 40−70% disease-control rate (DCR) in clinical trials on selected patients. This study evaluated real-life 2L+ nivolumab efficacy in MPM patients and looked for factors predictive of response.

Fractional Wigner Crystal in the Helical Luttinger Liquid.

The properties of the strongly interacting edge states of two dimensional topological insulators in the presence of two-particle backscattering are investigated. We find an anomalous behavior of the density-density correlation functions, which show oscillations that are neither of Friedel nor of Wigner type: they, instead, represent a Wigner crystal of fermions of fractional charge e/2, with e the electron charge. By studying the Fermi operator, we demonstrate that the state characterized by such fractional oscillations still bears the signatures of spin-momentum locking.

Parity measurement in topological Josephson junctions.

We study the properties of a topological Josephson junction made of both edges of a two-dimensional topological insulator. We show that, due to fermion parity pumping across the bulk, the global parity of the junction has a clear signature in the periodicity and critical value of the Josephson current. In particular, we find that the periodicity with the flux changes from 4π in a junction with an even number of quasiparticles to 2π in the odd sector.

Disordered one-dimensional bose-fermi mixtures: the Bose-Fermi glass.

We analyze an interacting Bose-Fermi mixture in a 1D disordered potential by using a combination of renormalization group and variational methods. We obtain the complete phase diagram in the incommensurate case as a function of bosonic and interspecies interaction strengths, in the weak disorder limit. We find that the system is characterized by several phase transitions between superfluid and various glassy insulating states, including a new Bose-Fermi glass phase, where both species are coupled and localized.

Comparison of blood activation in the wound, active vent, and cardiopulmonary bypass circuit.

Background: During cardiopulmonary bypass, aspirated blood exhibits strong activation features, but the triggering event remains unclear. Contact of blood with the pericardial cavity and surgical wound has been advocated as the main trigger, but suction forces are also considered as a possible contributor. We thus designed a study to identify the possible causes involved in this activation.