Publications by authors named "F Cozzolino"
The SARS-CoV-2 papain-like protease PLpro has multiple roles in the viral replication cycle, related to both its polypeptide cleavage function and its ability to antagonize the host immune response. Targeting the PLpro function is recognized as a promising mechanism to modulate viral replication, while supporting host immune responses. However, the development of PLpro-specific inhibitors remains challenging.
View Article and Find Full Text PDFSARS-CoV-2 encodes a 3C-like protease (3CL) that is essential for viral replication. This cysteine protease cleaves viral polyproteins to release functional nonstructural proteins, making it a prime target for antiviral drug development. We investigated the inhibitory effects of halicin, a known c-Jun N-terminal kinase inhibitor, on 3CL.
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- Ceres has notable amounts of aliphatic organics, with concentrations ranging from 5 to over 30 weight % in certain areas of its surface.
- The origins and longevity of these organics are questioned, especially since radiation levels in Ceres' orbit should typically break them down, complicating their detection.
- Laboratory experiments suggest that organic materials degrade quickly under radiation, indicating that buried organics may have been exposed in the recent past, and estimates show the initial abundance of aliphatics could be 2 to 30 times higher than what is currently observed.
Cyclin-dependent kinase-like 5 (CDKL5) is a serine/threonine protein kinase involved in human brain development and functioning. Mutations in CDKL5, especially in its catalytic domain, cause a severe developmental condition named CDKL5 deficiency disorder. Nevertheless, molecular studies investigating the structural consequences of such mutations are still missing.
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- Isolated amyloid deposition is common in stenotic aortic valves (AVs) among patients who do not have systemic or cardiac amyloidosis, with significant findings from a study of 130 patients undergoing cardiac surgery.
- In the study, amyloid was found in 37% of aortic stenosis valves, leading to higher levels of AV fibrosis and calcification, but no differences in clinical characteristics or survival rates were observed between those with and without amyloid deposition.
- The research suggests that local inflammation might contribute to amyloid deposition in AVs, highlighting its potential role in the pathophysiology of aortic stenosis despite its lack of direct clinical relevance.