Publications by authors named "F Coperchini"
Article Synopsis
- Homosalate is a common UV-B filter in sunscreens that has been found to have estrogenic and anti-androgenic effects in animal models, but its impact on thyroid cells is not well understood.
- This study tested the effects of Homosalate on two types of thyroid cells (FRTL-5 and NHT) over different concentrations and time periods, finding it significantly reduced cell viability in FRTL-5 at 250μM after 72 hours and in NHT only at the highest concentration (2000μM) after 48-72 hours.
- The results showed that high concentrations of Homosalate can cause cytotoxicity, exhibit genotoxic effects in rat thyroid cells, and increase the expression of
Inflamm-ageing: How cytokines and nutrition shape the trajectory of ageing.
Cytokine Growth Factor Rev
September 2024
Article Synopsis
- Population ageing is on the rise in developed countries, characterized by a decline in the functional capabilities of cells and organs, influenced heavily by inflammatory processes known as "inflamm-ageing."
- Inflamm-ageing is marked by an increase in pro-inflammatory molecules, leading to a chronic low-grade inflammatory state that can determine the overall health of elderly individuals, affecting whether they experience healthy or unhealthy ageing.
- Malnutrition is linked to worsened inflammatory responses and is a significant risk factor for sarcopenia (muscle mass loss), which contributes to frailty in the elderly, highlighting the interconnectedness of nutrition, inflammation, and the ageing process.
Objective: Radiofrequency ablation (RFA) is an emerging non-surgical treatment for benign thyroid nodules (BTN). Despite its proven safety profile, data on the learning curve (LC) required to achieve proficiency are still lacking.
Materials And Methods: The first 179 RFA procedures performed by a single operator in patients with non-functioning BTN were retrospectively analyzed.
Background: Thyroid cancer is the most common endocrine malignancy. Current therapies are successful, however some patients progress to therapeutically refractive disease. The immunotherapeutic potential of the CXCL8-chemokine/CXCR2-chemokine-receptor system is currently being explored in numerous human cancers.
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