Publications by authors named "F Cominelli"
Article Synopsis
- - The study focuses on how gut microorganisms impact Crohn's disease by causing immune responses that result in inflammation, particularly analyzing a new blend of probiotics and amylase in a mouse model of the disease.
- - Four groups of mice were treated for 56 days with different combinations of probiotics, amylase, or a control solution, and their inflammation levels and immune cell profiles were assessed.
- - Results showed that the probiotic + amylase blend significantly reduced inflammation and changed the abundance of immune cells, suggesting it may be an effective therapeutic option for managing Crohn's disease and warranting further clinical trials.
Constructing phylogenetic trees for microbiome data analysis: A mini-review.
Comput Struct Biotechnol J
December 2024
As next-generation sequencing technologies advance rapidly and the cost of metagenomic sequencing continues to decrease, researchers now face an unprecedented volume of microbiome data. This surge has stimulated the development of scalable microbiome data analysis methods and necessitated the incorporation of phylogenetic information into microbiome analysis for improved accuracy. Tools for constructing phylogenetic trees from 16S rRNA sequencing data are well-established, as the highly conserved regions of the 16S gene are limited, simplifying the identification of marker genes.
View Article and Find Full Text PDFUnderstanding the complex link between inflammation, gut health, and dietary amino acids is becoming increasingly important in the pathophysiology of inflammatory bowel disease (IBD). This study tested the hypothesis that a leucine-rich diet could attenuate inflammation and improve gut health in a mouse model of IBD. Specifically, we investigated the effects of a leucine-rich diet on dextran sulfate sodium (DSS)-induced colitis in germ-free (GF) SAMP1/YitFC (SAMP) mice colonized with human gut microbiota (hGF-SAMP).
View Article and Find Full Text PDFBackground/objectives: Dietary fats have been linked to the increasing incidence of chronic diseases, including inflammatory bowel diseases (IBD), namely, Crohn's disease (CD).
Methods: This study investigated the impact of pentadecanoic acid (C15:0), a type of an odd-numbered chain saturated fatty acid, for its potential anti-inflammatory properties in different mouse models of experimental IBD using the SAMP1/YitFc (SAMP) mouse line (14- or 24-week-old), including chronic ileitis and DSS-induced colitis. To quantitively assess the effect of C:15, we tested two dosages of C:15 in selected experiments in comparison to control mice.