An ancient river landscape preserved beneath the East Antarctic Ice Sheet.

The East Antarctic Ice Sheet (EAIS) has its origins ca. 34 million years ago. Since then, the impact of climate change and past fluctuations in the EAIS margin has been reflected in periods of extensive vs.

Rock organic carbon oxidation CO release offsets silicate weathering sink.

Mountain uplift and erosion have regulated the balance of carbon between Earth's interior and atmosphere, where prior focus has been placed on the role of silicate mineral weathering in CO drawdown and its contribution to the stability of Earth's climate in a habitable state. However, weathering can also release CO as rock organic carbon (OC) is oxidized at the near surface; this important geological CO flux has remained poorly constrained. We use the trace element rhenium in combination with a spatial extrapolation model to quantify this flux across global river catchments.

Image-Based Evaluation of In Vivo Degradation for Shape-Memory Polymer Polyurethane Foam.

Shape-memory polymer (SMP) polyurethane foams have been applied as embolic devices and implanted in multiple animal models. These materials are oxidatively degradable and it is critical to quantify and characterize the degradation for biocompatibility assessments. An image-based method using high-resolution and magnification scans of histology sections was used to estimate the mass loss of the peripheral and neurovascular embolization devices (PED, NED).

Diffusible contrast-enhanced micro-CT improves visualization of stented vessels.

In this report, we showcase diffusible iodine-based contrast-enhanced computed tomography (DICE-CT) as a method for improving soft tissue visualization and reducing beam hardening artifact within a stented vessel. This technique is commonly used in our pathology lab to image soft tissue specimens with dense metal implants and to ensure reliable morphological analysis through clear delineation of tissue structures. For this report, a porcine right coronary artery with an implanted metal stent was scanned using both conventional and DICE-CT methods.

Correlation of light microscopic findings with transmission electron microscopy within a vascular occlusion device.

Host response to an implanted biomaterial is a complex process involving microscopic changes in extracellular matrix (ECM) composition. Reliable pathology analysis is imperative for accurate assessment of the tissue response to an implanted device. Plastic histology is commonly used for histology evaluation of medical devices to assess the device-tissue interface; however, this technique is prone to variable staining that can confound histology interpretation.