Publications by authors named "F Claessens"
Article Synopsis
- * Higher catalase (CAT) activity was found in malignant cell lines compared to benign ones, contradicting previous findings, and reducing CAT expression through RNA interference led to increased proliferation in certain cancer cell lines.
- * Activation of the androgen receptor (AR) increases expression of enzymes that produce harmful oxidation in peroxisomes while decreasing CAT levels, suggesting that AR activity in PCa influences redox balance to support cancer cell survival and growth.
Article Synopsis
- Prostate cancer treatment resistance is a major challenge, with genomic studies revealing how cancer cells evade therapies, yet the tumor microenvironment's (TME) role remains unclear.
- A study using advanced techniques on samples from 120 patients offers a detailed transcriptomic profile of the prostate TME throughout the treatment process.
- The research highlights a unique cell type called club-like cells that interact with the immune system, suggesting their involvement in inflammation and resistance to androgen deprivation therapy, indicating they could be potential targets for new treatments.
Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.
View Article and Find Full Text PDFThe androgen receptor signaling inhibitor apalutamide is used successfully for the treatment of prostate cancer. An increased risk of hypothyroidism, mostly subclinical, has been reported in the SPARTAN and TITAN trials. We present three cases of subacute deterioration of previously known but well-controlled hypothyroidism treated with levothyroxine, occurring shortly after the initiation of treatment with apalutamide, resulting in severe hypothyroidism.
View Article and Find Full Text PDFBiological sex affects the activity of the hypothalamus-pituitary-adrenal (HPA) axis. However, how androgen deprivation affects this axis remains largely unknown. In this study, we investigated the effect of androgen status on different components of the HPA axis in male mice.
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