Publications by authors named "F Civantos"
Adenoid cystic carcinoma (ACC) is a rare and lethal malignancy that originates in secretory glands of the head and neck. A prominent molecular feature of ACC is the overexpression of the proto-oncogene MYB. ACC has a poor long-term survival due to its high propensity for recurrence and protracted metastasis.
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- - NUT carcinoma (NC) is a rare and aggressive cancer associated with a specific gene fusion resulting from a chromosomal translocation (t(15:19)), primarily found in the upper part of the body but also emerging in other areas.
- - Diagnosing NC is difficult based on appearance alone, but can be effectively done using specialized tests like immunohistochemistry for the NUT protein or by detecting the BRD4::NUTM1 fusion gene.
- - A recent case involved a 39-year-old man previously diagnosed with sinonasal squamous cell carcinoma, whose condition was reclassified to NC after further examination and testing, demonstrating the importance of accurate diagnosis for effective targeted treatment options currently in development.
Poorly differentiated thyroid carcinomas (PDTC) are rare diseases; nevertheless, they account for the majority of deaths from non-anaplastic follicular cell-derived thyroid carcinomas. Establishing the diagnosis and treatment of PDTC is challenging given the low incidence and the lack of standardization of diagnostic criteria. These limitations hamper the ability to compare therapeutic modalities and outcomes between recent and older studies.
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- The study aimed to see if adding local treatments, like surgery or radiation, improves survival for patients with metastatic oropharyngeal squamous cell carcinoma (OPSCC).
- Researchers analyzed data from the National Cancer Database from 2010 to 2015, focusing on patients who received systemic chemotherapy and comparing their overall survival based on treatment combinations.
- Results showed that local radiation therapy significantly improved survival rates, while local surgery did not offer a significant benefit; patients with HPV-positive tumors and those receiving multiagent chemotherapy had better overall survival outcomes.
Article Synopsis
- The study aimed to compare surgical outcomes for infranotch T4b oral cancers with T4a oral cancers by analyzing data from clinical studies.
- A total of 11,790 patients were reviewed, and findings indicated overall survival, disease-free survival, and disease-specific survival rates for IN-T4b patients.
- The meta-analysis concluded there were no significant differences in survival outcomes between IN-T4b and T4a oral cancers, suggesting that IN-T4b could be categorized as T4a.