Publications by authors named "F Cinque"
The role of noninvasive biomarkers for monitoring cell injury in advanced liver fibrosis.
Expert Rev Gastroenterol Hepatol
January 2025
Introduction: Accurate and reliable diagnosis and monitoring of hepatic fibrosis is increasingly important given the variable natural history in chronic liver disease (CLD) and expanding antifibrotic therapeutic options targeting reversibility of early-stage cirrhosis. This highlights the need to develop more refined and effective noninvasive techniques for the dynamic assessment of fibrogenesis and fibrolysis.
Areas Covered: We conducted a literature review on PubMed, from 1 December 1970, to 1 November 2024, to evaluate and compare available blood-based and imaging-based noninvasive tools for hepatic fibrosis diagnosis and monitoring.
Article Synopsis
- The study investigates the effectiveness of ultra-low-impact laparoscopy, which combines miniaturized instruments and regional anesthesia, for treating benign gynecological diseases.
- Conducted with 26 women, the study found minimal postoperative pain, quicker recovery times, and a low rate of nausea and vomiting, confirming the method's safety and efficacy.
- The positive outcomes suggest this technique could become a standard in gynecological surgery, warranting further research with more participants to validate its success.
Objectives: People with HIV are at increased risk for metabolic dysfunction-associated steatohepatitis (MASH). Although sex differences are documented in the general population, their role in the context of HIV is less understood.
Methods: This was a multicentre cohort study including people with HIV without viral hepatitis coinfection.
Article Synopsis
- - The recent FDA approval of resmetirom marks a significant advance in treating Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD), but lifestyle changes remain crucial for effective management amid a rising obesity crisis that often involves eating disorders.
- - Behavioral interventions like self-monitoring, goal setting, and cognitive behavioral therapy (CBT) are effective for weight loss and tackling binge eating, which is common in MASLD patients.
- - A comprehensive treatment for MASLD should combine pharmacotherapy with behavioral strategies, highlighting the importance of addressing both physical and psychological factors in managing this complex condition.
Article Synopsis
- Diabetes mellitus (DM) has significant impacts on kidney and liver functions, leading to conditions like diabetic kidney disease (DKD) and metabolic dysfunction-associated steatotic liver disease (MASLD).
- Management strategies for DKD include lifestyle changes and medications focusing on blood pressure and blood sugar control, while lifestyle modifications like weight loss and a Mediterranean diet are essential for MASLD.
- There's a critical need for screening and tailored care for patients with DM and liver issues, especially in unique populations such as those on hemodialysis or kidney transplant recipients, highlighting the importance of a multidisciplinary approach.