Publications by authors named "F Christ"
Role of LEDGF/p75 (PSIP1) in oncogenesis. Insights in molecular mechanism and therapeutic potential.
Biochim Biophys Acta Rev Cancer
February 2025
Aberrant gene expression due to dysfunction in proteins involved in transcriptional regulation is a hallmark of tumor development. Indeed, targeting transcriptional regulators represents an emerging approach in cancer therapeutics. Lens epithelium-derived growth factor (LEDGF/p75, PSIP1) is a co-transcriptional activator that tethers several proteins to the chromatin.
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- MeCP2 is a protein that regulates gene expression and chromatin structure, with two main forms, E1 and E2, and its mutations are linked to Rett syndrome.
- The study investigates how MeCP2 interacts with LEDGF, a transcription regulator, highlighting that the interaction requires a specific domain in MeCP2.
- Results show that a mutation in MeCP2 (R306C), associated with Rett syndrome, weakens its binding to LEDGF, indicating a complex role in maintaining chromatin organization.
Towards a comprehensive methodology for ecotoxicological assessment: Prioritizing plant protection products for mixture testing in edge-of-field surface waterbodies.
Sci Total Environ
December 2024
Article Synopsis
- Pesticide applications in agriculture create complex mixtures of Plant Protection Products (PPPs) in the environment, which may pose underestimated ecological risks that current regulations do not fully address.
- This study presents a new methodology to identify priority PPPs for further ecotoxicological testing in edge-of-field water and sediment systems, based on actual quantification from European and Argentine case studies.
- The research highlights discrepancies between EU risk assessment methods (ECHA vs. EFSA), with ECHA taking a more conservative approach, while EFSA offers a standardized strategy to avoid risk overestimations and provide a balanced view of PPP classes for mixture testing.
Lens epithelium-derived growth factor p75 (LEDGF/p75), member of the hepatoma-derived growth-factor-related protein (HRP) family, is a transcriptional co-activator and involved in several pathologies including HIV infection and malignancies such as MLL-rearranged leukemia. LEDGF/p75 acts by tethering proteins to the chromatin through its integrase binding domain. This chromatin interaction occurs between the PWWP domain of LEDGF/p75 and nucleosomes carrying a di- or trimethylation mark on histone H3 Lys36 (H3K36me2/3).
View Article and Find Full Text PDFThe widespread and extensive use of pesticides in European crop production to reduce losses from weeds, diseases, and insects may have serious consequences on the ecosystem and human health. This study aimed to identify 20 active substances of high health risk, based on their detection frequency within and across the environmental matrices (soil, crop, water, and sediment) and to identify their associated hazardous effects. A sampling campaign was conducted across 10 case study sites in Europe and 1 in Argentina and included conventional and organic farming systems.
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