Publications by authors named "F Chico"

Article Synopsis
  • * Group 4 (G4) MB, the most common subtype, is characterized by somatic mutations affecting the core binding factor alpha (CBFA) complex, including changes to genes like CBFA2T2 and OTX2.
  • * Research indicates that G4 MB cells resemble early progenitor cells in the cerebellar region but are stalled in development; targeting OTX2 may help overcome this block and allow these cells to mature normally.
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Endoscopic techniques are now an accepted part of the surgical armamentarium and are used routinely in a number of aesthetic and reconstructive procedures. Endoscopic techniques are now being used commonly by plastic surgeons in forehead and face lifts. In both craniofacial surgery and in neurosurgery, the application of endoscopy potentially allows the surgical team to perform wide dissection of the dura mater in a minimally invasive fashion, thereby potentially reducing the risk of dural and brain injury.

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The first nine clinical cases using endoscopic dissection of dura and craniotomy with minimal trephines were performed from June to August 1997 after trial dissection of 19 fresh cadavers conducted at the University of Brno's Pathology Institute in the Czech Republic. These procedures involved the refinement of craniofacial and intracranial surgical techniques using the endoscope and prototype instruments. These dissections demonstrated that intracranial structures can be explored using an endoscope without encumbrance, and that major craniofacial surgeries may also be performed with minor incisions and minimal craniotomies.

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The authors present a series of 66 cases of cerebrospinal fluid fistulas. Ways of localizing the fistula as well as different therapeutic methods are studied. They insist on the efficiency of external lumbar drainage of the cerebro-spinal fluid which permits a fair number of patients to recover without surgery.

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