Cardiovascular effects of dobutamine and converting enzyme inhibition in rats with diabetic ketoacidosis.

We investigated cardiac and peripheral hemodynamics in rats with streptozotocin-induced diabetes mellitus in comparison to normal controls. Diabetic rats showed a significantly decreased cardiac output and heart rate, with unchanged mean blood pressures. Regional blood flows were unchanged except for renal blood flow which was significantly lower.

Cardiovascular responses in the diabetic rat.

Cardiac and regional haemodynamics have been studied in 12- and 15-week-old streptozotocin-diabetic rats and in non-diabetic controls. Reduced cardiac output has been found in the 15-week-old diabetic rats (64 +/- 13 ml/min, mean +/- S.D.

Regional blood flows and cardiac hemodynamics in renovascular and mineralocorticoid hypertensive rats.

Regional blood flows and cardiac hemodynamics were studied in 3 models of hypertensive rats: one-kidney DOC-saline, one-kidney, one-clip and two-kidney, one-clip hypertension and in normotensive control rats. All hypertensive models were characterized by increased peripheral vascular resistance and normal cardiac output. Coronary and cerebral blood flows varied among the hypertensive models but did not significantly differ from the normotensive rats.

Renal haemodynamics in conscious experimentally hypertensive rats.

The integrity of renal haemodynamics is essential for the maintenance of normal renal function in the normotensive and hypertensive state. Systemic and renal haemodynamics have been determined by the radioactively labelled microspheres technique in normotensive, Goldblatt I, Goldblatt II and deoxycorticosterone (DOC)-saline-treated hypertensive rats. Cardiac output was similar between normotensive and hypertensive rats, while total peripheral resistance was similarly higher in all hypertensive animals when compared to normotensive animals.

Systemic and regional hemodynamic effects of propranolol in intact and anephric rats.

We studied the changes in systemic and regional hemodynamics (using the radioactive microsphere technique) and catecholamine levels produced by propranolol in conscious semi-restrained intact or nephrectomized rats. Blood pressure increased by 17 +/- 2 and 32 +/- 2 mmHg in intact and anephric rats respectively, total peripheral vascular resistance by 61.5% and 176.