Publications by authors named "F Celsi"
Photobiomodulation therapy (PBMT) is a form of treatment commonly used for routine clinical applications, such as wound healing of the skin and reduction of inflammation. Additionally, PBMT has been explored for its potential in pain relief. In this work, we investigated the effect of PBMT on ion content within the 50B11 sensory neurons cell line in vitro using X-Ray fluorescence (XRF) and atomic force microscope (AFM) analysis.
View Article and Find Full Text PDFAim: Management of primary healthcare and routine minor procedures for children with autism spectrum disorder (ASD) can be challenging; therefore, when behavioural strategies fail, sedative medications are often employed. We evaluated the effectiveness of the current pharmacological strategies for managing children with ASD.
Methods: We performed a systematic review and meta-analysis of the current approaches for procedural sedation in children with ASD.
Photobiomodulation therapy (PBMT) is known as a complementary tool to alleviate pain sensation in patients, nevertheless, there is still a gap of knowledge on its mechanism of action, thus limiting its clinical employment. In this study, a possible molecular mechanism of the 905 nm PBMT (0.25 W/cm ; 3, 6, 12, and 18 J/cm , 5 Hz) analgesic effect was tested on 50B11 cells, by investigating its impact on mitochondria.
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- Thalidomide is being used effectively to treat pediatric patients with inflammatory bowel disease (IBD) who do not respond to standard therapies, but its mechanism of action is not fully understood.
- The study involved ten pediatric IBD patients, using RNA sequencing to analyze the gene expression changes before and after 12 weeks of thalidomide treatment, revealing 378 differentially expressed genes.
- Findings suggest that thalidomide impacts key signaling pathways related to calcium, cAMP, eicosanoids, and neuronal signaling, indicating its immunomodulatory effects might involve the ubiquitin-proteasome pathway.
Article Synopsis
- This study investigated the unique morphology of 50B11 nociceptive sensory neurons in vitro, specifically their differentiation while cultured upside-down on cover glass supports.
- Using advanced microscopy techniques like multi-photon non-linear and second harmonic generation (SHG) microscopy, researchers observed enhanced neurite growth and microtubule organization in these inverted neurons.
- The findings suggest that inverted culture conditions could improve the 50B11 model for studying sensory neuron physiology related to various peripheral nervous system diseases and for testing analgesic drugs.