Publications by authors named "F Cavaleri"
Background: Current guidelines for the diagnosis and treatment of pericarditis refer to the general adult population. Few and fragmentary data regarding recurrent pericarditis in older adults exist.
Objective Of The Study: Given the absence of specific data in scientific literature, we hypothesized that there might be clinical, laboratory and outcome differences between young adults and older adults affected by idiopathic recurrent pericarditis.
Article Synopsis
- Ashwagandha has become popular for its various health benefits, including potential cancer-preventive properties, but its clinical use is limited due to inconsistent ingredient composition affecting treatment outcomes.
- The study explores an engineered ashwagandha extract called Oncowithanib, which contains a fixed amount of active ingredients, showing promising anti-cancer effects on the MCF7 cell line, including reduced cell viability and increased cell death.
- Findings suggest Oncowithanib targets key cellular mechanisms involved in cancer cell survival, highlighting the need for standardized herbal extracts to improve therapeutic effectiveness in cancer treatment.
Article Synopsis
- Ashwagandha extracts are important in traditional Indian medicine for treating various disorders, with withanolides being the key bioactive compounds that affect their potency and effectiveness.
- The study focuses on two specific ashwagandha extracts, ASH-Ext1 and ASH-Ext2, which have different proportions of withanolides, to explore their mechanisms of action.
- Results indicate that ASH-Ext1 enhances antioxidant activity and Nrf2 signaling, while ASH-Ext2 boosts specific protein levels linked to hair follicle health, highlighting the importance of standardizing extraction protocols for consistent therapeutic results.*
The immune response to infection plays a crucial role in the pathogenesis of COVID-19, but several patients develop a wide range of persistent symptoms, which is becoming a major global health and economic burden. However, reliable indicators are not yet available to predict the persistence of symptoms typical of the so-called long COVID. Our study aims to explore an eventual role of IL-6 levels as a marker of long COVID.
View Article and Find Full Text PDFThe onset of random X chromosome inactivation in mouse requires the switch from a symmetric to an asymmetric state, where the identities of the future inactive and active X chromosomes are assigned. This process is known as X chromosome choice. Here, we show that RIF1 and KAP1 are two fundamental factors for the definition of this transcriptional asymmetry.
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