Publications by authors named "F Casoni"
Growing evidence supports sleep-wake disruption as a mechanism involved in mood disorders pathogenesis. Duration of depressive episodes varies widely, and longer depressive episodes have been connected to worse outcomes. We aimed to explore if the length of depressive episodes is related to objective modifications of sleep features.
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- This study investigates how K-complexes (KC), a specific type of brainwave, relate to the effectiveness of Cognitive-Behavioral Therapy for Insomnia (CBT-I), which is the main treatment for chronic insomnia.
- Researchers conducted a multicenter study with 98 insomnia patients undergoing a 6-8 week CBT-I program, evaluating their sleep using polysomnography and an insomnia severity index before and after treatment.
- The results indicate that KC density, particularly its change after treatment, can predict how well patients respond to CBT-I and significantly correlates with improved sleep pressure, suggesting KC is an important biomarker for insomnia treatment.
Friedreich's ataxia (FRDA) is a neurodegenerative disorder characterized by severe neurological signs, affecting the peripheral and central nervous system, caused by reduced frataxin protein (FXN) levels. Although several studies have highlighted cellular dysfunctions in neurons, there is limited information on the effects of FXN depletion in astrocytes and on the potential non-cell autonomous mechanisms affecting neurons in FRDA. In this study, we generated a model of FRDA cerebellar astrocytes to unveil phenotypic alterations that might contribute to cerebellar atrophy.
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- The COVID-19 pandemic highlighted the benefits of telemedicine in Italy, leading to a focus on tele-visit services, particularly for type 1 diabetes patients in Modena.
- A case study was conducted to assess the implementation of these tele-visits over the first year, from May 2023 to April 2024, detailing the activities and challenges faced by the Local Health Authority.
- In the initial year, 72 patients participated with 103 tele-visits conducted, mostly involving women aged 30-49, with nearly half of the Diabetology specialists engaged in the service.
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- Researchers explored the differences between "brain-first" and "body-first" types of Parkinson's disease by studying patients with isolated REM sleep behavior disorder (iRBD) and their periodic limb movements during sleep (PLMS).
- Out of the 191 patients examined, 48.2% had a high PLMS index (PLMSi > 15), which was linked to better performance in executive functions despite poorer sleep quality.
- The study suggests that higher PLMSi correlates with increased wakefulness and decreased overall sleep efficiency, indicating a potential connection between sleep disruptions and cognitive status in these patients.