Comparative study of lactoferrin and other blood markers of inflammatory stress between preeclamptic and normal pregnancies.

Objective: To test lactoferrin as a blood discriminator of neutrophil activation between normal and preeclamptic pregnancy.

Design: Comparative study between normal (n = 40) and preeclamptic women receiving treatment (n = 42) in the third trimester of pregnancy and in the post partum period (30 women with normal pregnancy and 22 with preeclampsia).

Methods: Blood, serum or plasma measurements of neutrophils, lactoferrin, vitamin C, vitamin E, lipid peroxidation products, elastase, C-reactive protein (CRP), gamma-glutamyltranspeptidase (gamma GT), haptoglobin, osmotic fragility, urea, creatinine, uric acid, transaminases (ASAT, ALAT), lactic dehydrogenase (LDH), platelets, red and white blood cells.

Lactoferrin as a sensitive blood marker of neutrophil activation in normal pregnancies.

Objective: To test lactoferrin as a marker of neutrophil activation during pregnancy.

Design: Cross-sectional study in normal pregnant (n = 100), nonpregnant (n = 11) and post partum women (n = 30).

Methods: Serum or plasma measurements of neutrophils, lactoferrin, vitamin C, vitamin E, lipid peroxide, elastase, C-reactive protein gamma-glutamyltranspeptidase, haptoglobin and osmotic fragility.