Powder Metallurgy Processing to Enhance Superelasticity and Shape Memory in Polycrystalline Cu-Al-Ni Alloys: Reference Material for Additive Manufacturing.

Shape memory alloys (SMAs) are functional materials with a wide range of applications, from the aerospace sector to the biomedical field. Nowadays, there is a worldwide interest in developing SMAs through powder metallurgy like additive manufacturing (AM), which allows innovative building processes. However, producing SMAs using AM techniques is particularly challenging because of the microstructure required to obtain optimal functional properties.

Complement and microglia activation mediate stress-induced synapse loss in layer 2/3 of the medial prefrontal cortex in male mice.

Spatially heterogeneous synapse loss is a characteristic of many psychiatric and neurological disorders, but the underlying mechanisms are unclear. Here, we show that spatially-restricted complement activation mediates stress-induced heterogeneous microglia activation and synapse loss localized to the upper layers of the medial prefrontal cortex (mPFC) in male mice. Single cell RNA sequencing also reveals a stress-associated microglia state marked by high expression of the apolipoprotein E gene (Apoe) localized to the upper layers of the mPFC.

Results from Arm A of Phase 1/2 DREAMM-6 trial: belantamab mafodotin with lenalidomide plus dexamethasone in patients with relapsed/refractory multiple myeloma.

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Valorisation of Aggregate-Washing Sludges in Innovative Applications in Construction.

The valorisation of sludges from aggregate production into construction materials is required for full circularity in mining waste management. This study explores valorisation pathways, relevant regulatory frameworks, and End-of-Waste (EoW) criteria for specific settings in Spain and Norway. The explored valorisation routes involved the production of filler, supplementary cementitious materials (SCMs), and lightweight aggregates (LWAs) for the production of cement-based products, and precursors for 3D printed construction material.

Effects of chronic stress on cognitive function - From neurobiology to intervention.

Exposure to chronic stress contributes considerably to the development of cognitive impairments in psychiatric disorders such as depression, generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), post-traumatic stress disorder (PTSD), and addictive behavior. Unfortunately, unlike mood-related symptoms, cognitive impairments are not effectively treated by available therapies, a situation in part resulting from a still incomplete knowledge of the neurobiological substrates that underly cognitive domains and the difficulty in generating interventions that are both efficacious and safe. In this review, we will present an overview of the cognitive domains affected by stress with a specific focus on cognitive flexibility, behavioral inhibition, and working memory.