Publications by authors named "F Carbonnel"
Article Synopsis
- - Gastrointestinal immune-related adverse events (GI irAEs) are a frequent issue linked to immune checkpoint inhibitors (ICIs), impacting various parts of the GI system, including the stomach, liver, and pancreas.
- - A systematic review was conducted using multiple databases, leading to the analysis of 166 studies focused on GI irAEs, examining their incidence, management strategies, and patient outcomes.
- - The review covers different types of GI toxicity related to ICIs, including upper GI (like esophagitis), lower GI (such as colitis), and other rare forms, aiming to provide clinicians with insights for better diagnosis and treatment.
Article Synopsis
- Heatwaves are increasing in frequency and duration, yet there is a lack of accessible environmental data for primary care use; this study aims to create an online mapping tool to help assess community vulnerability to heatwaves.
- Conducted as a participatory action-research project in France, the study engaged key stakeholders, including primary care practitioners and data scientists, to collaboratively identify data variables affecting heatwave vulnerability.
- The findings indicate the importance of co-creating tools that integrate environmental data into primary care, highlighting the potential to enhance health assessments and address broader planetary health issues.
Article Synopsis
- The study focuses on SB5, an adalimumab biosimilar approved in Europe in 2017, and aims to gather real-world data on its usage and effectiveness in patients with various immune-mediated inflammatory diseases (IMIDs).
- Researchers analyzed clinical and healthcare claims data from the French national healthcare database to assess patient persistence on SB5 after 12 months.
- Among 911 patients treated with SB5, notable remission rates were observed at the 12-month mark, particularly in naïve patients, across various conditions such as rheumatoid arthritis and Crohn's disease, with all showing significant improvement from baseline.
Background: Practice-based research is one of the levers identified by the World Health Organization (WHO) to strengthen primary health care. The scaling of health and social care innovations has the potential to reduce inequities in health and to expand the benefits of effective innovations. It is now rapidly gaining the attention of decision-makers in health and social care, particularly in high-income countries.
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