Publications by authors named "F Capel"
Article Synopsis
- The Special Issue of the Journal of Physiology and Biochemistry highlights 7 contributions from the long-running "Consortium of Trans-Pyrenean Investigations on Obesity and Diabetes" (CTPIOD), which focuses on understanding obesity, diabetes, and related diseases.
- The research primarily involves collaborative efforts from groups in France and Spain, but invites participation from other countries as well, emphasizing molecular and physiological mechanisms, prevention, and therapy.
- Many contributions stem from the 19th Conference held in Jaca, Spain, where lectures discussed the role of specific fatty acids and phytochemicals in preventing metabolic disorders, prompting original research submissions for this issue.
Myosteatosis occurs in response to excess circulating fatty acids and is associated with muscle dysfunction. This study aimed to characterize the sequence of events of lipid-induced toxicity within muscle cells and the role of polyunsaturated fatty acids (PUFA) as potential preventive factors. Myosteatosis was induced in C2C12 myotubes exposed to palmitic acid (PAL 500µM).
View Article and Find Full Text PDFSarcopenic obesity (SO) is defined as the combination of excess fat mass (obesity) and low skeletal muscle mass and function (sarcopenia). The identification and classification of factors related to SO would favor better prevention and diagnosis. The present article aimed to (i) define a list of factors related with SO based on literature analysis, (ii) identify clinical conditions linked with SO development from literature search and (iii) evaluate their relevance and the potential research gaps by consulting an expert panel.
View Article and Find Full Text PDFImportance: Sarcopenia and obesity are 2 global concerns associated with adverse health outcomes in older people. Evidence on the population-based prevalence of the combination of sarcopenia with obesity (sarcopenic obesity [SO]) and its association with mortality are still limited.
Objective: To investigate the prevalence of sarcopenia and SO and their association with all-cause mortality.
TRUEFAD (TRUE Fiber Atrophy Distinction) is a bioimagery user-friendly tool developed to allow consistent and automatic measurement of myotube diameter in vitro, muscle fiber size and type using rodents and human muscle biopsies. This TRUEFAD package was set up to standardize and dynamize muscle research via easy-to-obtain images run on an open-source plugin for FIJI. We showed here both the robustness and the performance of our pipelines to correctly segment muscle cells and fibers.
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