The effect of analgesic state on implicit learning during propofol anesthesia in volunteers.

Noxious stimulation may enhance implicit learning during general anesthesia. It is unknown, however, whether analgesic state can influence this memory processing. Twenty healthy adult volunteers were enrolled our prospective, double-blinded, controlled experiments.

Absence of implicit and explicit memory during propofol/remifentanil anaesthesia.

Background And Objective: High doses of opioid associated with low doses of hypnotic is a popular anaesthetic technique since the use of remifentanil has become widespread. This type of anaesthesia could result in a higher incidence of implicit memory.

Methods: Ten patients were anaesthetised with a target-controlled infusion of remifentanil (target concentration of 8 ng mL(-1)) combined with a target-controlled infusion of propofol with progressive stepwise increases until loss of consciousness was reached.

Use of the sequential organ failure assessment score as a severity score.

Objective: To evaluate whether the SOFA score can be used to develop a model to predict intensive care unit (ICU) mortality in different countries.

Design And Setting: Analysis of a prospectively collected database. Patients with ICU stay longer than 2 days were studied to develop a mortality prediction model based on measurements of organ dysfunction.

Effect site concentrations of remifentanil and pupil response to noxious stimulation.

Background: Opioid drugs block reflex pupillary dilatation in response to noxious stimulation. The relationship between the target effect site concentration (Ce(T)) of remifentanil and the pupil diameter and reactivity in response to a standard noxious stimulus were evaluated.

Methods: Anaesthesia was induced with propofol TCI to obtain loss of consciousness (LOC) in 12 ASA I/II patients.

Absence of explicit and implicit memory in unconscious patients using a TCI of propofol.

Background: Episodes of implicit memory have been described during propofol anaesthesia. It remains unclear whether implicit memory is caused by short periods of awareness or occurs in an unconscious subject.

Methods: Sixty patients were randomized in an experimental group (EG), a control group (CG) and a reference group (RG).