Publications by authors named "F Canals"
The MIA40 relay system mediates the import of small cysteine-rich proteins into the intermembrane mitochondrial space (IMS). MIA40 substrates are synthesized in the cytosol and assumed to be disordered in their reduced state in this compartment. As they cross the outer mitochondrial membrane, MIA40 promotes the oxidation of critical native disulfides to facilitate folding, trapping functional species in the IMS.
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- The oxidation of histone H3 at lysine 4 (H3K4ox) is catalyzed by LOXL2 and is found in triple-negative breast cancer (TNBC) cells, where it maintains compacted chromatin.* -
- LOXL2 interacts with key proteins (RUVBL1, RUVBL2, ACTL6A, DMAP1) that are essential for incorporating the histone variant H2A.Z, which plays a role in chromatin structure.* -
- Without LOXL2 or RUVBL2, levels of important heterochromatin markers are reduced, impacting the oncogenic features of TNBC cells, suggesting that this molecular interplay is crucial for cancer
Article Synopsis
- - The study explored the use of Direct Oral Drug Provocation Test (DODPT) to safely assess beta-lactam antibiotic (BLA) allergies in children, revealing that over 90% of suspected cases could be ruled out effectively.
- - It involved 2,133 young patients across 15 hospitals in Spain, noting that most had mild reactions; only a handful experienced severe reactions, such as anaphylaxis, which resolved quickly with treatment.
- - The results suggest that DODPT is a reliable method for confirming or denying BLA allergies, making it a practical option for doctors in pediatric care to help "delabel" unnecessary allergies.
Epithelial/Mesenchymal (E/M) plasticity plays a fundamental role both in embryogenesis and during tumorigenesis. The receptor for advanced glycation end products (RAGE) is a driver of cell plasticity in fibrotic diseases; however, its role and molecular mechanism in triple-negative breast cancer (TNBC) remains unclear. Here, we demonstrate that RAGE signaling maintains the mesenchymal phenotype of aggressive TNBC cells by enforcing the expression of SNAIL1.
View Article and Find Full Text PDFPurpose: Tumor antigens are central to antitumor immunity. Recent evidence suggests that peptides from noncanonical (nonC) aberrantly translated proteins can be presented on HLA-I by tumor cells. Here, we investigated the immunogenicity of nonC tumor HLA-I ligands (nonC-TL) to better understand their contribution to cancer immunosurveillance and their therapeutic applicability.
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