Publications by authors named "F Caloni"
The inherent adaptability of human mesenchymal stromal cells (hMSCs) to differentiate into neural lineages provides a valuable resource for investigating potential neurotoxicity in humans. By harnessing the ability of hMSCs to transform into astrocytes, we can evaluate the effects of various agents on these vital cells. Our protocol employs hMSCs sourced from umbilical cord tissue, ensuring a readily available supply of high-quality cells.
View Article and Find Full Text PDFCopper is an essential trace element but becomes toxic in overexposed animals. Sheep are the domestic species most prone to chronic copper poisoning, as a slight increase in the dietary concentration can lead to liver accumulation and the development of clinical signs in this species. Common sources of copper in the diet are feed additives and mineral supplements, which are commonly used in pigs and poultry.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the cytotoxic effects of methylglyoxal (MGO) on human-derived 3D neuronal spheroids, a model that mimics human brain cells, particularly in relation to aging and neurodegenerative diseases.
- Results show that MGO leads to decreased cell viability and growth at low concentrations, with significant cellular damage observed at higher doses, including necrosis and apoptosis.
- The findings highlight the potential of using these complex 3D models to evaluate the impact of MGO and other harmful agents, providing insights into mechanisms of neurodegeneration and aging.