Public Health.

Background: Ethnic and racial diversity in clinical research is critical for developing generalizable treatments and caregiving strategies. Barriers to participation among persons from underrepresented groups (URG) are systemic in clinical research. To increase URG research participation, we designed a community-based data collection site where study participants complete full research visits.

Public Health.

Background: Individuals' attitudes toward research predict recruitment, engagement, and retention. The Research Attitudes Questionnaire (RAQ), developed to predict individuals' willingness to participate, is often used in AD research. It can be used to identify strategies to mitigate individuals' reluctance to engage in research.

Public Health.

Background: To increase participation of underrepresented groups (URG) into clinical research studies such as the AHEAD study, a study assessing lecanemab in participants with preclinical Alzheimer's disease (AD), it is necessary to understand and address barriers in an effort to mitigate them. Toward this goal, methods assessing community needs and plans to meet those needs are imperative. Our ultimate goal is to aid URG in understanding the clinical research process and to empower them to participate in AD research so that approved therapies are applicable to them.

Public Health.

Background: Non-Hispanic Black Americans (BA) have increased prevalence of cardiovascular disease (CVD) risk factors and elevated risk for end-stage renal disease (ESRD). CVD risk factors, and potentially ESRD, heighten dementia risk; however, the association of CVD risk and kidney function to cognition in cognitively unimpaired (CU) BA adults remains understudied. We tested whether global CVD risk, individual CVD risk factors, and less healthy kidney function moderated associations between age and cognitive performance in middle-aged to older adult BAs who were CU at baseline.

Perceptions about preclinical Alzheimer's disease biomarker collection procedure influences willingness to participate: Findings from an ethnoracially diverse study.

Background: Past research suggests that ethnoracialized groups differ in their willingness to engage in preclinical Alzheimer's disease (AD) research overall. Studies indicated that participation willingness was affected by attitudes toward research and perceived invasiveness of biomarker collection techniques. However, comparative quantitative studies are few, and minoritized groups are under-included.