Peptide YY inhibition of prostaglandin-induced intestinal secretion is haloperidol-sensitive in humans.

Background & Aims: It is uncertain whether peptide YY (PYY) inhibits human intestinal secretion directly through enterocyte receptors or via indirect neural mechanisms. Thus, the effect of PYY on prostaglandin E2 (PGE2)-induced jejunal secretion in normal volunteers was measured, and it was determined whether a dopamine and sigma antagonist affected PYY effect.

Methods: Jejunal absorption of water and electrolytes was measured by a perfusion method in 6 volunteers.