Publications by authors named "F C WILSON"
Homozygous MTAP deletion occurs in ~15% of cancers, making them vulnerable to decreases in the concentration of S-adenosylmethionine (SAM). AG-270/S095033 is an oral, potent, reversible inhibitor of methionine adenosyltransferase 2 A (MAT2A), the enzyme primarily responsible for the synthesis of SAM. We report results from the first-in-human, phase 1 trial of AG-270/S095033 as monotherapy in patients with advanced malignancies (ClinicalTrials.
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- The study investigates CP symmetry violation in the decay of D^{+} particles into K^{-}K^{+}π^{+} using data from proton-proton collisions at a high energy of 13 TeV.
- A unique model-independent method was employed to analyze the phase-space distributions of D^{+} and D^{-} particles, correcting for any instrumental biases using D_{s}^{+} decays.
- The findings indicate no significant evidence of CP violation, with a p value of 8.1%, and measure specific CP asymmetry observables, marking this study as the most sensitive search of its kind in multibody decays.
Aim: To understand the experience and care needs of older people living with vision impairment in the acute hospital setting.
Design: A qualitative study using co-productive user-based design.
Methods: Seven older people living with vision impairment and six healthcare students collaborated in a series of six researcher facilitated co-productive workshops.
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- This study examined how playing multiple seasons of rugby affects serum S100B levels in male professional players and the acute impact of concussion on these levels.
- Researchers collected blood samples during different seasons of play and after concussions to measure S100B concentrations using an ELISA assay.
- The results showed that while S100B levels remained stable across seasons, they significantly increased immediately after concussions, but returned to pre-season levels by the end of the season, suggesting S100B could be a valuable tool in managing sports-related concussions.
This cross-sectional study aims to identify the situational characteristics, ball-carrier technical variables, and recommended techniques associated with performance outcomes in elite women's Rugby Union. Using retrospective video analysis, 43 tackler and ball-carrier technical characteristics for 1500 tackle events in the 2022-23 Women's Six Nations Championship were assessed, considering match situation and performance outcomes. Rate ratio (RR) was determined using propensity rates.
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