Dendritic cells in triple-negative breast cancer: From pathophysiology to therapeutic applications.

Breast cancer is the second most commonly diagnosed cancer in women and the fifth leading cause of cancer-related deaths worldwide. It is a highly heterogeneous disease, consisting of multiple subtypes that vary significantly in clinical characteristics and survival outcomes. Triple-negative breast cancer (TNBC) is a particularly aggressive and challenging subtype of breast cancer.

Single and combined chronic toxicity of cadmium and titanium dioxide nanoparticles in Aquarana catesbeiana (Anura: Ranidae) tadpoles.

The rising production and improper disposal of titanium dioxide nanoparticles (TiO NPs) into aquatic systems present considerable environmental challenges, especially when these particles interact with other contaminants such as cadmium (Cd). Thus, the current study aimed to evaluate the potential toxic effects on the gills, chondrocranium, body growth, and mortality of Aquarana catesbeiana tadpoles. The tadpoles were exposed to environmentally relevant concentrations of TiO NPs (10 µg L), and CdCl (10 µg L), both individually and in combination, for 30 days (chronic exposure), along with a control group.

First report of a cat (Felis catus) infected by Leishmania (Viannia) guyanensis from Southeastern Brazil.

Feline leishmaniasis is increasingly recognized as a disease affecting cats worldwide, with notable prevalence in regions surrounding the Mediterranean Basin and in Brazil. An approximately one-year-old domestic shorthair cat was presented with small papules and nodules (2 mm) on the nasal planum. Physical examination and routine blood analyses were normal.

A PI3Kδ-Foxo1-FasL signaling amplification loop rewires CD4 T helper cell signaling, differentiation and epigenetic remodeling.

While inputs regulating CD4 T helper cell (Th) differentiation are well-defined, the integration of downstream signaling with transcriptional and epigenetic programs that define Th-lineage identity remain unresolved. PI3K signaling is a critical regulator of T cell function; activating mutations affecting PI3Kδ result in an immunodeficiency with multiple T cell defects. Using mice expressing activated-PI3Kδ, we found aberrant expression of proinflammatory Th1-signature genes under Th2-inducing conditions, both and .