Publications by authors named "F C Perez-Martinez"
Article Synopsis
- The study focuses on the synthesis of five small molecules featuring a guanidine core through guanylation reactions, a key method in medicinal chemistry.
- These compounds were tested against various strains of bacteria, including extended-spectrum beta-lactamase (ESBL) producers and methicillin-resistant Staphylococcus aureus (MRSA), using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) tests.
- Results indicate that these guanidine-core molecules show potential as new treatments for bacterial infections, especially against drug-resistant strains, suggesting further research is necessary to optimize their effectiveness.
Considering both biological and non-biological polygonal shape organizations, in this paper we introduce a quantitative method which is able to determine informational entropy as spatial differences between heterogeneity of internal areas from simulation and experimental samples. According to these data (i.e.
View Article and Find Full Text PDFis one of the species with the greatest clinical importance and greatest impact on public health. In fact, methicillin-resistant (MRSA) is considered a pandemic pathogen, being essential to develop effective medicines and combat its rapid spread. This study aimed to foster the translation of clinical research outcomes based on metallodrugs into clinical practice for the treatment of MRSA.
View Article and Find Full Text PDFNanotechnology is a developing field that has boomed in recent years due to the multiple qualities of nanoparticles (NPs), one of which is their antimicrobial capacity. We propose that NPs anchored with 2-(dimethylamino)ethyl methacrylate (DMAEMA) have antibacterial properties and could constitute an alternative tool in this field. To this end, the antimicrobial effects of three quaternised NPs anchored with DMAEMA were studied.
View Article and Find Full Text PDFA bis(pyrazolyl)methane derivative against clinical strains isolated from otitis externa.
Laryngoscope Investig Otolaryngol
February 2022
Objective: The purpose of this study was to evaluate the in vitro antibacterial effects of a Cymene-based bis(pyrazolyl)methane derivative (SC-19) to advance in developing alternative therapeutic compounds to fight against bacterial isolates from patients with otitis externa (OE).
Methods: Eighteen swab specimens were collected from patients aged over 18 years diagnosed with OE within at least 7 days of symptom onset, contaminated by only one bacterium type: ( = 5); ( = 8); ( = 2); ( = 1); ( = 2). To appraise antibacterial activity, minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), minimum biofilm inhibitory concentration (MBIC), and minimum biofilm eradication concentration (MBEC) assays were run at different SC-19 concentrations.