Publications by authors named "F C MacDonald"

The Snowball Earth hypothesis predicts global ice cover; however, previous descriptions of Cryogenian (720-635 Ma) glacial deposits are limited to continental margins and shallow marine basins. The Tavakaiv (Tava) sandstone injectites and ridges in Colorado, USA, preserve a rare terrestrial record of Cryogenian low-latitude glaciation. Injectites, ridges, and chemically weathered crystalline rock display features characteristic of fluidization and pervasive deformation in a subglacial environment due to glacial loading, fluid overpressure, and repeated sand injection during meltwater events.

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Article Synopsis
  • Vasomotor symptoms (VMS) are common in breast cancer patients and can negatively impact quality of life and treatment adherence if not properly managed.
  • A study was conducted where patients selected from four interventions to manage their VMS, and effectiveness was measured using a validated scale at 6 weeks, with a new weighted score developed to assess change in symptoms.
  • Results indicated that the severity of VMS at the start influenced patients' perception of treatment effectiveness, and those with lower baseline symptoms didn't notice significant changes; thus, targeted interventions should focus on patients with moderate to high baseline symptoms.
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Interferon gamma (IFN) is a potent antiviral cytokine that can be produced by many innate and adaptive immune cells during infection. Currently, our understanding of which cells produce IFN and where they are located at different stages of an infection is limited. We have used reporter mice to investigate expression of mRNA in the lung and secondary lymphoid organs during and following influenza A virus (IAV) infection.

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The ~2,000-km-long Central Range of New Guinea is a hotspot of modern carbon sequestration due to the chemical weathering of igneous rocks with steep topography in the warm wet tropics. These high mountains formed in a collision between the Australian plate and ophiolite-bearing volcanic arc terranes, but poor resolution of the uplift and exhumation history has precluded assessments of the impact on global climate change. Here, we develop a palinspastic reconstruction of the Central Range orogen with existing surface geological constraints and seismic data to generate time-temperature paths and estimate volumes of eroded material.

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The Cryogenian Sturtian and Marinoan Snowball Earth glaciations bracket a nonglacial interval during which Demosponge and green-algal biomarkers first appear. To understand the relationships between environmental perturbations and early animal evolution, we measured sulfur and mercury isotopes from the Datangpo Formation from South China. Hg enrichment with positive ΔHg excursion suggests enhanced volcanism, potentially due to depressurization of terrestrial magma chambers during deglaciation.

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