Comparison of skin biopsy triage decisions in 49 patients with pigmented lesions and skin neoplasms: store-and-forward teledermatology vs face-to-face dermatology.

Objective: To determine the relative efficacy of store-and-forward teledermatology vs face-to-face dermatology consultations in triage decisions about the need for a biopsy of neoplastic skin changes.

Design: Prospective study of consecutive patients judged by an internist to require dermatologic consultation for a skin growth.

Setting: Private primary care and dermatology practices and an academic dermatology practice.

Xeroradiographic observations in four patients with chronic renal disease and cutaneous gangrene.

Cutaneous gangrene developed in four patients who had chronic renal disease that resulted in secondary hyperparathyroidism and systemic arterial calcification. Three of the four patients showed a unique pattern, by xeroradiography, of extensive medical calcification in subcutaneous arterioles. This noninvasive procedure demonstrated calcium in minute subcutaneous arterioles.

The pathway of adenylate catabolism in Azotobacter vinelandii. Evidence for adenosine monophosphate nucleosidase as the regulatory enzyme.

Cell-free, dialyzed extracts from Azotobacter vinelandii rapidly dephosphorylate [U-14C]ATP to labeled ADP and AMP, which is then degraded to hypoxanthine, the end product of AMP catabolism under the experimental conditions which were used. The intermediates of the pathway from ATP to hypoxanthine have been identified by thin layer chromatography and quantitated by the 14-C content. The concentrations of intermediates present during the production of hypoxanthine are consistent with AMP nucleosidase being responsible for AMP degradation in these extracts.