Publications by authors named "F C KUIPERS"
Article Synopsis
- Recent advancements in aging research and drug discovery connect basic research with clinical applications, aiming to promote healthy longevity in humans.* -
- The Aging Research and Drug Discovery Meeting in 2023 highlighted key areas such as AI, biomarkers, geroscience, and clinical trials focused on enhancing healthspan.* -
- The meeting emphasized the importance of combining generative AI with innovative biological technologies to tackle age-related diseases and extend healthy lifespans.*
Article Synopsis
- The trans intestinal cholesterol excretion (TICE) pathway is a strategy to lower LDL cholesterol by promoting the direct excretion of cholesterol from enterocytes into feces, which was previously stimulated in mice using hydrophilic bile acids.* -
- A clinical trial tested whether the bile acid ursodeoxycholic acid (UDCA) could increase fecal cholesterol excretion in humans, involving 20 male participants who received either UDCA or a placebo after a run-in with ezetimibe.* -
- Results showed that while UDCA did increase the hydrophilicity of bile acids, it did not elevate fecal neutral sterols nor decrease LDL cholesterol levels, indicating TICE may not be influenced by bile acid hydroph
Article Synopsis
- - Elevated levels of plasma bile acids (BAs) in Cyp2c70 mice lead to changes in heart gene expression, indicating stress and inflammation related to cardiac health in early life.
- - RNA sequencing revealed 1355 differentially expressed genes in the hearts of mice with high versus low plasma BAs, with many linked to inflammatory processes and cardiovascular disease.
- - Treatment with ursodeoxycholic acid (UDCA) during pregnancy normalized many of the affected cardiac genes, suggesting potential therapeutic benefits for managing cardiac issues related to elevated BAs.
Background: Bile's potential to reflect the health of the biliary system has led to increased attention, with proteomic analysis offering deeper understanding of biliary diseases and potential biomarkers. With the emergence of normothermic machine perfusion (NMP), bile can be easily collected and analyzed. However, the composition of bile can make the application of proteomics challenging.
View Article and Find Full Text PDFArticle Synopsis
- - This study tested the effects of a 14-day L2-7 supplement on blood sugar levels in 25 White Dutch men with type 2 diabetes who were already taking metformin.
- - Results showed that the supplement significantly reduced variations in blood sugar levels and improved blood pressure compared to a placebo, but did not significantly change levels of short-chain fatty acids or bile acids.
- - While the L2-7 supplement was well-tolerated and effective, the authors suggest that more studies with larger and more diverse groups are needed to confirm these findings.