Publications by authors named "F C Haase"
Chimeric antigen receptor (CAR) T cell (CAR-T) therapies present options for patients diagnosed with certain leukemias. Recent advances of the technology included a method to integrate the CAR into the T cell receptor alpha constant (TRAC) locus to take advantage of the endogenous promoter and regulatory elements for CAR expression. This method used adeno-associated viral (AAV) vectors based on AAV6 to deliver the donor template encoding the CAR construct.
View Article and Find Full Text PDFRetention of microplastics by biofilms and their ingestion by protists in rivers.
Environ Microbiol Rep
October 2024
Article Synopsis
- Microplastics (MPs) are generated by human activities and travel from rivers to the ocean, with biofilms in aquatic ecosystems potentially influencing their distribution and ingestion by organisms.
- A study in the River Rhine showed that biofilms collected from clay tiles contained significantly higher amounts of MPs compared to the surrounding water, with a majority of these particles being less than 50 micrometers.
- Laboratory findings demonstrated that biofilm-covered tiles captured 6-12 times more MPs, and experiments confirmed that the ciliate Stentor coeruleus ingests these particles, indicating their potential impact on aquatic life and particle transport models.
Covalent Organic Frameworks (COFs) exhibiting kagome () structures are promising crystalline porous materials with two distinct pores. However, there are no reliable synthetic methods to exclusively target the over the polymorphic square-lattice () structure. To address this, we introduce a linker design strategy featuring bulky functional groups, which through steric interactions can hinder the net formation, thereby leading to a structure.
View Article and Find Full Text PDFArticle Synopsis
- White lupin (Lupinus albus L.) is a high-protein alternative to soybean in Central Europe but faces challenges from the fungal disease anthracnose, which impacts yield, and alkaloid management for nutrition.
- The study involved genotyping and phenotypic analysis of various white lupin genotypes for resistance to anthracnose, and assessed seed alkaloid and protein levels using technologies like genotyping by sequencing and near-infrared spectroscopy.
- Results showed some breeding lines with anthracnose resistance rivaling top commercial cultivars, while genome-wide association studies identified significant SNP markers for disease resistance and nutritional traits, aiding future breeding programs for improved white lupin.
Novel AAV variants with improved tropism for human Schwann cells.
Mol Ther Methods Clin Dev
June 2024
Gene therapies and associated technologies are transforming biomedical research and enabling novel therapeutic options for patients living with debilitating and incurable genetic disorders. The vector system based on recombinant adeno-associated viral vectors (AAVs) has shown great promise in recent clinical trials for genetic diseases of multiple organs, such as the liver and the nervous system. Despite recent successes toward the development of novel bioengineered AAV variants for improved transduction of primary human tissues and cells, vectors that can efficiently transduce human Schwann cells (hSCs) have yet to be identified.
View Article and Find Full Text PDF