Publications by authors named "F C H Bakers"
Hepatocellular carcinoma (HCC) is, to date, the most common malignant tumor of the liver and is commonly staged with the Milan criteria. While deceased-donor liver transplantations (DDLT) are reserved for patients within the Milan criteria, living-donor liver transplantation (LDLT) might be a curative option for patients outside the Milan criteria. We here report a case of a 32-year-old woman who developed a giant, unresectable HCC out of a hepatocellular adenoma (HCA) after a pregnancy.
View Article and Find Full Text PDFHyperferritinemia and liver iron content determined with MRI: Reintroduction of the liver iron index.
Clin Res Hepatol Gastroenterol
December 2023
Article Synopsis
- Hyperferritinemia affects about 12% of the population, and determining its cause can be challenging, particularly differentiating between normal iron levels and significant iron overload, often assessed through liver MRI.
- Previous guidelines recommend using the liver iron index (LII) from biopsy data, but this study investigates whether LII based on MRI (LII-MRI) of ≥2 can effectively indicate major iron overload by comparing the amount of iron needed for depletion among hyperferritinemia patients.
- Findings indicate that significantly more iron needed to be mobilized in patients with LII-MRI ≥2, and those with lower LII-MRI were more likely to have conditions related to metabolic syndrome, suggesting LII-M
Objectives: To develop and validate a multiparametric model to predict neoadjuvant treatment response in rectal cancer at baseline using a heterogeneous multicenter MRI dataset.
Methods: Baseline staging MRIs (T2W (T2-weighted)-MRI, diffusion-weighted imaging (DWI) / apparent diffusion coefficient (ADC)) of 509 patients (9 centres) treated with neoadjuvant chemoradiotherapy (CRT) were collected. Response was defined as (1) complete versus incomplete response, or (2) good (Mandard tumor regression grade (TRG) 1-2) versus poor response (TRG3-5).
Aims: The aim of this study is to evaluate whether agreement with autopsy-determined cause of death (COD) increases by use of postmortem CT (PMCT) or PMCT in combination with postmortem sampling (PMS), when compared with clinical assessment only.
Methods: This prospective observational study included deceased patients from the intensive care unit and internal medicine wards between October 2013 and August 2017. The primary outcome was percentage agreement on COD between the reference standard (autopsy) and the alternative postmortem examinations (clinical assessment vs PMCT or PMCT+PMS).
Background And Purpose: Dose-escalation in rectal cancer (RCa) may result in an increased complete response rate and thereby enable omission of surgery and organ preservation. In order to implement dose-escalation, it is crucial to develop a technique that allows for accurate image-guided radiotherapy. The aim of the current study was to determine the performance of a novel liquid fiducial marker (BioXmark®) in RCa patients during the radiotherapy course by assessing its positional stability on daily cone-beam CT (CBCT), technical feasibility, visibility on different imaging modalities and safety.
View Article and Find Full Text PDF