Publications by authors named "F C Fitzgerald"
Nature utilizes bioreversible post-translational modifications (PTMs) to spatiotemporally diversify protein function. Mimicking Nature's approach, chemists have developed a variety of chemoselective regents for traceless, bioreversible modification of native proteins. These strategies have found utility in the development of reversible covalent inhibitors and degraders as well as the synthesis of functional protein conjugates for delivery into cells.
View Article and Find Full Text PDFObjectives: An effective vaccine for chicken pox has been included in immunisation schedules since the 1990s. In the UK the recommendation for routine inclusion came in November 2023; it has not yet been implemented. We explored paediatricians' attitudes towards the vaccine and their personal and professional use; as this has been shown to be an influential factor in parents' vaccine decision making.
View Article and Find Full Text PDFArticle Synopsis
- During autumn/winter 2022, the UK saw an unusual rise in severe group A streptococcal infections in children, primarily manifesting as pneumonia with fluid in the lungs.
- Clinicians documented 185 cases from children under 16, revealing that most patients were healthy prior to infection, with many also suffering from respiratory viral coinfections.
- The study underscores the importance of routine vaccinations against common viruses and group A streptococcus, as well as the effectiveness of molecular testing to aid in diagnosis and reporting.