Publications by authors named "F C Erdmann"
Purpose: The COVID-19 pandemic was associated with severe disruptions in healthcare worldwide. Cancer patients are at particular risk of adverse consequences from delays in diagnosis and treatment. To evaluate the available data on the impact of the pandemic on cancer diagnoses, oncological care and patient well-being in Germany, the German Society for Epidemiology (DGEpi) in collaboration with the Epidemiological Cancer Registry of Lower Saxony invited to a workshop on "COVID & Cancer" (held on 26-27 October 2023 in Hanover, Germany).
View Article and Find Full Text PDFIncidence and Temporal Patterns of Differentiated Thyroid Carcinoma in Children and Adolescents in Germany: A Pooled Analysis Based on Data from the German Malignant Endocrine Tumor Registry and the German Childhood Cancer Registry.
Thyroid
December 2024
Article Synopsis
- The study analyzes the rising incidence of differentiated thyroid carcinoma (DTC) among children and adolescents in Germany over 25 years, using data from two significant registries.
- A total of 469 DTC cases were identified, predominantly papillary thyroid cancer, with the average age-specific incidence rate rising especially among females and adolescents aged 15-17.
- The findings show an overall increase in pediatric DTC, highlighting improved detection methods while raising concerns about potential underlying health factors contributing to this trend.
Class I HDACs are considered promising targets for cancer due to their role in epigenetic modifications. The main challenges in developing a new, potent and non-toxic class I HDAC inhibitor are selectivity and appropriate pharmacokinetics. The PROTAC technique (Proteolysis Targeting Chimera) is a new method in drug development for the production of active substances that can degrade a protein of interest (POI) instead of inhibiting it.
View Article and Find Full Text PDFArticle Synopsis
- Researchers studied how surviving childhood leukemia (ALL) might affect mental health as kids grow up.
- They looked at almost 2,000 survivors and compared them to their siblings and other kids to see who had more psychiatric problems by age 30.
- They found that survivors had a slightly higher chance of mental health issues, especially those who had serious treatments, but overall, the risks were similar to their siblings and friends.
Introduction: Transitioning to adulthood often involves achieving independence from the parental home. We assessed whether the likelihood of leaving the parental home, cohabitation, and marriage was similar between patients who experienced a hematologic malignancy at a young age and their peers.
Methods: We identified 11,575 patients diagnosed with a hematologic malignancy under the age of 20 years between 1971 and 2011 in Denmark, Finland, and Sweden, 57,727 country-, age-, and sex-matched population comparisons and 11,803 sibling comparisons and obtained annual information on family and marital status by linking to the statistical institute databases.