Publications by authors named "F C Chapman"
Objective: Differentiating between arginine vasopressin deficiency (AVP-D) and primary polydipsia (PP) requires a copeptin stimulation test. We aimed to characterize changes in apelin, an endogenous hormone antagonizing AVP, upon copeptin stimulation tests.
Design: Post hoc secondary analysis of a multi-centric cross-over diagnostic study (NCT03572166).
Article Synopsis
- Chronic kidney disease (CKD) affects around 10% of people and is often linked to cardiovascular complications, with current treatments yielding poor outcomes, highlighting the need for new therapies.
- A study was conducted with 24 participants (12 with CKD and 12 healthy) to evaluate the effects of apelin-13, which resulted in improved cardiovascular and renal parameters, like increased renal blood flow and decreased blood pressure when administered at higher doses.
- The findings suggest that apelin can offer short-term benefits for both the heart and kidneys in CKD patients, and if sustained, may enhance patient outcomes, prompting the need for further clinical trials on long-acting apelin therapies.
Objective: Health programs for Indigenous people are most effective, acceptable, and sustainable when Indigenous perspectives are prioritized. Codesign builds on Indigenous people's creativity and propensity to experiment with new technologies and ensures research is designed and implemented in a culturally safe and respectful manner. Limited research has focused on older Indigenous people as partners in digital health.
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- Chest compressions are essential for maintaining good blood flow during CPR in cardiac arrest patients, as pauses can drastically lower arterial blood pressure (ABP).
- The study analyzed data from patients receiving mechanical CPR with the LUCAS device in Oslo, examining the influence of compression pauses on ABP recovery.
- Results showed that ABP quickly returned to over 90% of pre-pause levels within just 1.7 seconds after two compressions, indicating that pause duration did not significantly impact ABP recovery.