Publications by authors named "F C Alexander"
The exon capture approach allows for sequencing a large number of loci to reconstruct phylogenetic relationships at varying taxonomic levels. In order to efficiently recover the targeted loci, the probes designed to capture the exons need to be genetically sufficiently similar to bind to the DNA, with a proposed limit of 10% of divergence. However, this threshold has never been tested with a specific protocol.
View Article and Find Full Text PDFArticle Synopsis
- The study assesses the return to performance of MLB pitchers after undergoing ulnar collateral ligament (UCL) surgery using advanced analytics and pitch-tracking metrics.
- At 1, 2, and 3 years post-surgery, the data showed that only 1.6% of pitchers returned to play within the first year, but the rates increased significantly to 71.9% at 2 years and 82.0% at 3 years.
- The research highlights the importance of modern metrics, examining factors like expected fielding independent pitching and velocity, to evaluate pitchers' recovery and performance levels after surgery.
Molecular design based on generative models, such as variational autoencoders (VAEs), has become increasingly popular in recent years due to its efficiency for exploring high-dimensional molecular space to identify molecules with desired properties. While the efficacy of the initial model strongly depends on the training data, the sampling efficiency of the model for suggesting novel molecules with enhanced properties can be further enhanced via latent space optimization (LSO). In this paper, we propose a multi-objective LSO method that can significantly enhance the performance of generative molecular design (GMD).
View Article and Find Full Text PDFBackground: Tuberculosis remains a significant global health concern, especially for People Living with HIV, who are at an increased risk of severe TB disease. Despite the availability of TB Preventive Treatment, knowledge gaps persist among People Living with HIV regarding its importance, accessibility, and administration. The study aimed to assess TPT knowledge levels and determinants among People Living with HIV in Tanzania.
View Article and Find Full Text PDFPredraft elbow magnetic resonance imaging in Major League Baseball pitchers.
J Shoulder Elbow Surg
November 2024
Background: Prior to the Major League Baseball (MLB) draft, some pitchers undergo predraft magnetic resonance imaging (MRI). This study aimed to evaluate pre-draft elbow MRI on baseball pitchers who were entering the MLB draft to determine the presence or absence of pathology, the associations between these pathologies and ulnar collateral ligament (UCL) tears, and interobserver reliability regarding common MRI pathology.
Methods: Predraft elbow MRI performed on prospective MLB pitchers between 2011 and 2017 were deidentified and then reviewed by two separate authors.