Publications by authors named "F Byrne"
Background: The metabolic pathway of de novo lipogenesis (DNL) is upregulated in fatty liver disease and liver cancer. Inhibitors of DNL are in development for the treatment of these disorders; however, our previous study showed that blocking DNL unexpectedly exacerbated liver tumorigenesis when liver acetyl-CoA carboxylase (ACC) 1 and 2 enzymes were deleted in mice treated with diethylnitrosamine (DEN) and fed high fat diet. Herein, we used 3 new approaches including ACC1 vs.
View Article and Find Full Text PDFA 51-year-old female, with no previous history of psychosis, presented to the Emergency Department with an acute psychotic episode in the context of excess caffeine consumption. Caffeine is an adenosine antagonist. An antagonist of adenosine can lead to the release of dopamine into the synaptic cleft, which can induce psychotic symptoms in vulnerable individuals.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores combining the thyroid hormone receptor (THR)-β agonist resmetirom (MGL) with the mitochondrial uncoupler BAM15 to enhance treatment for metabolic dysfunction-associated steatohepatitis (MASH), since over 60% of MGL patients do not see improvement.
- - Male mice were treated with either MGL, BAM15, both, or no treatment for 8 weeks after being on a GAN diet for 38 weeks, with evaluations based on body weight, energy expenditure, and liver health.
- - The combination of MGL and BAM15 led to greater improvements in liver fat loss, energy usage, and glucose control compared to either drug alone, suggesting potential benefits of combination therapy
Background: The post-release period is associated with an increased risk of morbidity and mortality. Previous studies have identified deficits in pre-release planning for mentally ill people in prison, particularly in remand settings.
Objectives: We aimed to determine the proportion of mentally ill people in Ireland's main remand prison who were referred for mental health follow up in community and prison settings, who achieved face to face contact with the receiving service.