Microbiota promotes recruitment and pro-inflammatory response of caecal macrophages during E. tenella infection.

Background: Eimeria genus belongs to the apicomplexan parasite phylum and is responsible for coccidiosis, an intestinal disease with a major economic impact on poultry production. Eimeria tenella is one of the most virulent species in chickens. In a previous study, we showed a negative impact of caecal microbiota on the physiopathology of this infection.

The caecal microbiota promotes the acute inflammatory response and the loss of the intestinal barrier integrity during severe infection.

Introduction: Coccidiosis, a disease caused by intestinal apicomplexan parasites , is a threat to poultry production. is one of the most pathogenic species, frequently causing a high prevalence of opportunistic infections.

Objective: The objective of this study is to investigate the role of the microbiota in the pathogenesis of severe infection.

Flow patterns and pathways of legacy and contemporary pesticides in surface waters in tropical volcanic catchments.

Severe water pollution issues due to legacy and contemporary pesticides exist in tropical regions and are linked to cash crops requiring intensive plant protection practices. This study aims to improve knowledge about contamination routes and patterns in tropical volcanic settings to identify mitigation measures and analyse risk. To this aim, this paper analyses four years of monitoring data from 2016 to 2019 of flow discharge and weekly pesticide concentrations in the rivers of two catchments grown predominantly with banana and sugar cane in the French West Indies.

Overexpression of Eimeria tenella Rhoptry Kinase 2 Induces Early Production of Schizonts.

Eimeria tenella is an obligate intracellular parasite responsible for avian coccidiosis. Like other apicomplexan parasites, such as Toxoplasma gondii, cell invasion and intracellular development rely on apical organelle content discharge, named micronemes and rhoptries. Some rhoptry (ROP) kinases (ROPK) are key virulence factors in T.

Genome-Wide Expression Patterns of Rhoptry Kinases during the Life-Cycle.

Kinome from apicomplexan parasites is composed of eukaryotic protein kinases and Apicomplexa specific kinases, such as rhoptry kinases (ROPK). is a gene family that is known to play important roles in host-pathogen interaction in but is still poorly described in , the parasite responsible for avian coccidiosis worldwide. In the genome, 28 genes are predicted and could be classified as active ( = 7), inactive (incomplete catalytic triad, = 12), and non-canonical kinases (active kinase with a modified catalytic triad, = 9).