Publications by authors named "F Buemi"
Assessing functional outcomes in Severe Closed Head Injury (SCHI) is complex due to brain parenchymal changes. This study examines the Ventricles to Intracranial Volume Ratio (VBR) as a metric for these changes and its correlation with behavioral scales. Thirty-one SCHI patients were included.
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- - A case study of a 32-year-old man who ingested chlorine bleach illustrates the potential health risks, from mild burns to severe complications, including the development of hepatic portal venous gas (HPVG), which can be alarming but is not always life-threatening.
- - HPVG in this case resolved without intervention within 24 hours, highlighting its transient nature, while the exact reasons for its occurrence after ingesting toxic substances are not fully understood.
- - Although HPVG can indicate serious conditions, it may also arise in less severe cases that can be treated conservatively, with hyperbaric oxygen therapy recommended for cases presenting neurological symptoms.
Background: Immune-checkpoint inhibitors (ICIs) are an effective therapeutic strategy, improving the survival of patients with lung cancer compared with conventional treatments. However, novel predictive biomarkers are needed to stratify which patients derive clinical benefit because the currently used and highly heterogenic histological PD-L1 has shown low accuracy. Liquid biopsy is the analysis of biomarkers in body fluids and represents a minimally invasive tool that can be used to monitor tumor evolution and treatment effects, potentially reducing biases associated with tumor heterogeneity associated with tissue biopsies.
View Article and Find Full Text PDFBackground: Immune-checkpoint inhibitors (ICIs) changed the therapeutic landscape of patients with lung cancer. However, only a subset of them derived clinical benefit and evidenced the need to identify reliable predictive biomarkers. Liquid biopsy is the non-invasive and repeatable analysis of biological material in body fluids and a promising tool for cancer biomarkers discovery.
View Article and Find Full Text PDFThe extracellular protease ADAMTS-7 has been identified as a potential therapeutic target in atherosclerosis and associated diseases such as coronary artery disease (CAD). However, ADAMTS-7 inhibitors have not been reported so far. Screening of inhibitors has been hindered by the lack of a suitable peptide substrate and, consequently, a convenient activity assay.
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