Publications by authors named "F Brilot"

Introduction: The autoimmune encephalitides (AE) are a heterogeneous group of neurological disorders with significant morbidity and healthcare costs. Despite advancements in understanding their pathophysiology, uncertainties persist regarding long-term prognosis and optimal management. This study aims to address these gaps, focusing on immunotherapeutic strategies, neoplastic associations and functional outcomes.

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Background: Current literature informs us that bivalent vaccines will generate a broader serum neutralizing antibody response to multiple SARS-CoV-2 variants, but studies on how this breadth relates to the memory B cell (MBC) and T cell responses are sparse. This study compared breadth of neutralising antibody, and memory B and T cell responses to monovalent or a bivalent ancestral/Omicron BA.1 COVID-19 booster vaccine.

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Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is one of the most common antibody-mediated CNS disorders. Optimal diagnostic and prognostic biomarkers remain unclear. Our aim was to clarify these biomarkers and therapeutic outcomes internationally.

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Article Synopsis
  • Ongoing research is essential for tracking and understanding the emergence of new SARS-CoV-2 variants, particularly as diagnostic testing declines in Australia during the COVID-19 pandemic.
  • In 2023, collaborations with pathology and genomics teams allowed for the monitoring of SARS-CoV-2 variants in New South Wales through various methods, including viral culture and analysis of immune responses from a large pool of blood donations.
  • Findings indicated that while existing antibodies generally neutralized many variants, specific mutations in emerging strains, particularly JN.1, suggested future challenges in controlling their spread due to enhanced transmissibility.
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Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is diagnosed by serum MOG-immunoglobulin G (MOG-IgG) in association with typical demyelination. 111/1127 patients with paired CSF/serum samples were seropositive for MOG-IgG. Only 7/1016 (0.

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