Publications by authors named "F Bosse"
Contrary to the adult central nervous system, the peripheral nervous system has an intrinsic ability to regenerate that relies on the expression of regeneration-associated genes, such as some kinesin family members. Kinesins contribute to nerve regeneration through the transport of specific cargo, such as proteins and membrane components, from the cell body towards the axon periphery. We show here that KIF4A, associated with neurodevelopmental disorders and previously believed to be only expressed during development, is also expressed in the adult vertebrate nervous system and up-regulated in injured peripheral nervous system cells.
View Article and Find Full Text PDFHigh resolution mass spectrometry images are of increasing importance in biological applications, such as the study of tissues and single cells. Two promising techniques for this are matrix-enhanced secondary ion mass spectrometry (ME-SIMS) and matrix-assisted laser desorption/ionization (MALDI). For both techniques, the sample of interest must be coated with a matrix prior to analysis, and analytes must migrate into the matrix.
View Article and Find Full Text PDFArticle Synopsis
- Recent advances in diagnosis and treatment have led to an increase in adults living with congenital heart disease (ACHD), but this population faces challenges, particularly with rhythm disorders, which we aimed to study in relation to heart rate variability (HRV) and its impact on prognosis.
- A study involving 97 ACHD patients and 19 controls revealed that ACHD patients exhibited higher instances of premature ventricular contractions and lower HRV measurements compared to controls, with significant statistical differences indicating potential health risks.
- The findings also showed that specific HRV metrics correlated with NT-proBNP levels, and during a follow-up period, there were notable differences in HRV parameters between patients who experienced cardiac events and those who remained event-free, highlighting the prognostic value of
Time-of-flight secondary ion mass spectrometry is one of the most promising techniques for label-free analysis of biomolecules with nanoscale spatial resolution. However, high-resolution imaging of larger biomolecules such as phospholipids and peptides is often hampered by low yields of molecular ions. Matrix-enhanced SIMS (ME-SIMS), in which an organic matrix is added to the sample, is one promising approach to enhancing the ion yield for biomolecules.
View Article and Find Full Text PDFPurpose: Advances in treatment enables most patients with congenital heart diseases (CHD) to survive into adulthood, implying the need to address comorbid conditions in this growing cohort of patients. The aim of this study was to evaluate the prevalence of sleep-disordered breathing (SDB) and lung function abnormalities in patients with adult congenital heart disease (ACHD).
Methods: Patients with ACHD underwent level 3 sleep testing (Embletta MPR polygraphy) and pulmonary function testing.