Publications by authors named "F Bosques-Padilla"
Article Synopsis
- Alcohol-associated hepatitis (AH) has high mortality rates, with up to 40% of patients dying within 6 months, partly due to increased susceptibility to infections that worsen their condition.
- A study analyzed the immune responses of 36 healthy individuals, 48 patients with alcohol use disorder, and 224 AH patients, finding that abstaining from alcohol boosts antibody responses, while AH patients had reduced antiviral and antibacterial antibodies linked to worse outcomes.
- The research indicates that a lower level of antiviral antibodies in AH patients can predict liver disease complications and mortality, suggesting that serum viral epitope signatures could be valuable for assessing patient prognosis.
Biliary tract complications after orthotopic liver transplantation (OLT) are frequently reported. The diagnosis and management of these complications have become increasingly crucial, with digital single operator cholangioscopy (DSOC) emerging as an essential tool. We describe the approach to biliary complications using DSOC in 5 patients post-OLT.
View Article and Find Full Text PDFObjective: Patients with alcohol-associated hepatitis (AH) have a high mortality. Alcohol exacerbates liver damage by inducing gut dysbiosis, bacterial translocation and inflammation, which is characterised by increased numbers of circulating and hepatic neutrophils.
Design: In this study, we performed tandem mass tag (TMT) proteomics to analyse proteins in the faeces of controls (n=19), patients with alcohol-use disorder (AUD; n=20) and AH (n=80) from a multicentre cohort (InTeam).
Introduction: Crohn's disease (CD) is a subtype of chronic and incurable inflammatory bowel disease. It can affect the entire gastrointestinal tract and its etiology is unknown.
Objective: The aim of this consensus was to establish the most relevant aspects related to definitions, diagnosis, follow-up, medical treatment, and surgical treatment of Crohn's disease in Mexico.
Background And Aims: Patients with alcohol-associated hepatitis (AH) have an altered fecal metabolome, including reduced microbiota-derived tryptophan metabolites, which function as ligands for aryl hydrocarbon receptor (AhR). The aim of this study was to assess serum AhR ligand activity in patients with AH.
Approach And Results: The study included 74 controls without AUD, 97 patients with AUD, and 330 patients with AH from 2 different multicenter cohorts (InTeam: 134, AlcHepNet: 196).