Publications by authors named "F Bosetti"
Article Synopsis
- - The Stroke Preclinical Assessment Network (SPAN) was created to address concerns about the reliability of preclinical testing for new stroke treatments, following recent failures in clinical trials.
- - SPAN conducted a rigorous multi-laboratory trial using various animal models to assess candidate treatments in a controlled manner, ensuring aspects like treatment masking and randomization were properly implemented.
- - By following a standardized protocol across six labs and successfully enrolling a large number of animals, SPAN aims to enhance reproducibility in preclinical research, potentially applying its framework to other medical research areas.
The Stroke Preclinical Assessment Network (SPAN) is a multicenter preclinical trial platform using rodent models of transient focal cerebral ischemia to address translational failure in experimental stroke. In addition to centralized randomization and blinding and large samples, SPAN aimed to introduce heterogeneity to simulate the heterogeneity embodied in clinical trials for robust conclusions. Here, we report the heterogeneity introduced by allowing the 6 SPAN laboratories to vary most of the biological and experimental model variables and the impact of this heterogeneity on middle cerebral artery occlusion (MCAo) performance.
View Article and Find Full Text PDFCerebral ischemia and reperfusion initiate cellular events in brain that lead to neurological disability. Investigating these cellular events provides ample targets for developing new treatments. Despite considerable work, no such therapy has translated into successful stroke treatment.
View Article and Find Full Text PDF