Genomics in cereals: from genome-wide conserved orthologous set (COS) sequences to candidate genes for trait dissection.

Recent updates in comparative genomics among cereals have provided the opportunity to identify conserved orthologous set (COS) DNA sequences for cross-genome map-based cloning of candidate genes underpinning quantitative traits. New tools are described that are applicable to any cereal genome of interest, namely, alignment criterion for orthologous couples identification, as well as the Intron Spanning Marker software to automatically select intron-spanning primer pairs. In order to test the software, it was applied to the bread wheat genome, and 695 COS markers were assigned to 1,535 wheat loci (on average one marker/2.

[Fatal rupture of the ventricular strut of a Björk-Shiley prosthesis in mitral position. Description of a case, review of the literature and elements of differential diagnosis].

We describe a fatal case of outlet strut's fracture of a Björk-Shiley mitral valve prosthesis with displacement of the disc in left ventricular cavity. The acute, catastrophic nature of the symptoms associated with massive transvalvular regurgitation preclude survival except with immediate operation; consequently, we describe the clinical and instrumental elements for a very early diagnosis.

[Echo-phonomechanocardiographic relations of the systolic time intervals of the left ventricle (author's transl)].

15 normal subjects and 23 subjects with cardiac valve disease have been studied. All the subjects have undergone an echo-phonomechanocardiographic investigation with simultaneous recording of the tracings. The values of the systolic time intervals have been obtained from the echo-cardiographic tracings and compared with those obtained from the phonomechanocardiographic tracings evaluating the differences between them.