Hair reconstruction of the burned chin region using a pre-expanded free temporo-parietal skin flap. About a case.

Reconstruction of the chin region represents a technical challenge due to its three-dimensional configuration and its location close to the mouth. It requires both a functional approach by restoring mobility and an aesthetic approach by restoring the perioral furrows. For men who want to wear a beard, it becomes more difficult to choose the donor site for hairy skin.

Cancer-associated fibroblast spatial heterogeneity and expression in the tumor microenvironment modulate TGF-β activity and CD8 T-cell infiltration in breast cancer.

The tumor microenvironment (TME) and its multifaceted interactions with cancer cells are major targets for cancer treatment. Single-cell technologies have brought major insights into the TME, but the resulting complexity often precludes conclusions on function. We combined single-cell RNA sequencing and spatial transcriptomic data to explore the relationship between different cancer-associated fibroblast (CAF) populations and immune cell exclusion in breast tumors.

[Sociological aspects of transgenrism].

The surgery of trans people is not apprehended by most of plastic surgeons as a simple surgery for the purpose of morphological transformation. At the same time, the French trans population does not benefit from adequate surgical coverage. Over the past few years, French regulations have simplified the process of reassignment surgeries.

Inferring ligand-receptor cellular networks from bulk and spatial transcriptomic datasets with BulkSignalR.

The study of cellular networks mediated by ligand-receptor interactions has attracted much attention recently owing to single-cell omics. However, rich collections of bulk data accompanied with clinical information exists and continue to be generated with no equivalent in single-cell so far. In parallel, spatial transcriptomic (ST) analyses represent a revolutionary tool in biology.

[Burns caused by nitrous oxide cylinder misuse].

Unlabelled: In recent years, we have seen an increase in the frequency of the misuse of nitrous oxide as a narcotic. The risks associated with its use are now well-known, such as neurological and psychiatric risks. In this study, we report our experience with specific thigh burns when using nitrous oxide canisters for narcotic purposes.