Surgical Treatment of Gastric GIST: Feasibility of Laparoscopic Resection and Postoperative Outcome.

Objective: The aim of this study is to evaluate clinical manifestations and the possibility of laparoscopic treatment of large gastric stromal tumors.

Study Design: A case-series. Place and Duration of the Study: Ist Surgical Unit, Saint Spiridon Hospital Iasi and the Ist Oncological Surgical Unit, Regional Institute of Oncology Iasi, Romania, from May 2012 to May 2017.

Glycated albumin is correlated with glycated hemoglobin in type 2 diabetes.

Background And Aims: Glycated hemoglobin (HbA1c) retrospectively evaluates mean glycemia in the preceding 2-3 months and is the gold standard for assessing glycemic control, while glycated albumin (GA) is currently considered a short to intermediate term integrated glycemic control marker, since it reflects glycemic status over the last 3 weeks. We aimed to investigate the levels of GA, HbA1c and fasting glycemia in a group of patients with type 2 diabetes.

Methods: The observational study included adult type 2 diabetes patients (n=135) according to inclusion and exclusion criteria, randomly selected from Clinical Centre of Diabetes, Cluj-Napoca, Romania.

Class II correction in orthodontic patients utilizing the Mandibular Anterior Repositioning Appliance (MARA).

Objectives: To evaluate skeletal and dentoalveolar changes produced by the Mandibular Anterior Repostioning Appliance (MARA) in the treatment of Class II malocclusion in adolescent patients.

Materials And Methods: Lateral cephalograms of 24 patients, mean age 12.40 years, with a Class II malocclusion consecutively treated with MARA were compared with a historical control group.

ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility.

N(6)-methyladenosine (m(6)A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another mammalian demethylase that oxidatively reverses m(6)A in mRNA in vitro and in vivo. This demethylation activity of ALKBH5 significantly affects mRNA export and RNA metabolism as well as the assembly of mRNA processing factors in nuclear speckles.

Contributions to the study of morphofunctional interrelations in the liver of the rats treated with certain antipsychotic drugs.

The issue of antipsychotics in psychiatry constituted a revolution at the time. The firsts, starting with chlorpromazine represent the conventional antipsychotics, in the last decades there was a new generation of antipsychotics, atypical, which improved the results in treating psychoses. Because, as any drug, it may have adverse effects we aimed an experimental study on rats to observe the toxic potential on liver of both generations of antipsychotics.