Publications by authors named "F Bobinski"
Ayahuasca Pretreatment Prevents Sepsis-Induced Anxiety-Like Behavior, Neuroinflammation, and Oxidative Stress, and Increases Brain-Derived Neurotrophic Factor.
Mol Neurobiol
November 2024
The psychoactive decoction Ayahuasca (AYA) used for therapeutic and religious purposes by indigenous groups and peoples from Amazonian regions produces anti-inflammatory and neuroprotective effects. Thus, it may be useful to attenuate the neuroinflammation and related anxiety- and depressive-like symptoms elicited by inflammatory insults such as sepsis. Rats were pretreated for 3 days with different doses of AYA.
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- There is a growing concern over the lack of effective treatments for mild cognitive impairment (MCI), which is increasingly prevalent due to an aging population, and transcranial photobiomodulation (t-PBM) using near-infrared light may offer a solution.
- The study evaluated various cognitive and emotional outcomes in 93 older adults with MCI, comparing those receiving t-PBM therapy to a placebo group, over a period of 150 days.
- Results showed that t-PBM significantly enhanced cognition scores and increased levels of the neuroplasticity biomarker BDNF, indicating a potential therapeutic benefit for individuals with MCI.
To analyze the muscle trophism and expression of interleukin-6 in the biceps brachii muscle of rats with incomplete cervical spinal cord injury treated with neuromuscular electrical stimulation (NMES). Adult rats underwent C5-C7 spinal cord hemisection and a 5-week NMES protocol. Trophism of the biceps brachii was assessed using muscle weight/body weight ratio and histological analysis.
View Article and Find Full Text PDFObjective: The objective of this study was to estimate the accuracy of measuring neck circumference as a diagnostic method for overweight in 10-year-old children.
Methods: A cross-sectional diagnostic accuracy study was performed in 2019. The population was composed of 942 school children from the municipality of Palhoça, SC, Brazil.
Background: In response to inflammation and other stressors, tryptophan is catalyzed by Tryptophan 2,3-Dioxygenase (TDO), which leads to activation of the kynurenine pathway. Sepsis is a serious condition in which the body responds improperly to an infection, and the brain is the inflammation target in this condition.
Objective: This study aimed to determine if the induction of TDO contributes to the permeability of the Blood-Brain Barrier (BBB), mortality, neuroinflammation, oxidative stress, and mitochondrial dysfunction, besides long-term behavioral alterations in a preclinical model of sepsis.